Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: a retrospective observational study

Table 3 Variables associated with delayed cerebral ischemia and functional outcome in 46 subarachnoid hemorrhage patients with Takotsubo cardiomyopathy on multivariate analysis ^a

Covariates	Odds ratio (95% confidence interval)	P-value
DCI
WFNS grade IV or V	1.64 (0.07 – 5.87)	0.70
Duration of low CFI, days	2.14 (1.33 – 2.84)	0.004*
Coexist pulmonary edema (ELWI >14 ml/kg) after day 4	1.66 (0.32 – 2.21)	0.36
Poor functional outcome at 3-month follow-up
WFNS grade IV or V	1.17 (0.46 – 3.76)	0.20
DCI	1.68 (0.07 – 7.29)	0.39
Duration of low CFI, days	1.87 (1.06 – 3.29)	0.02*
Pulmonary edema after day 4	2.10 (1.11 – 3.97)	0.04*
Length of ICU stay, days	1.93 (0.54 – 1.41)	0.59

^aCFI: Cardiac function index; DCI: Delayed cerebral ischemia; ELWI: Extravascular lung water index; WFNS: World Federation of Neurological Surgeons. Poor functional outcome was defined as modified Rankin Scale scores of 4 to 6. Pulmonary edema was defined as ELWI >14 ml/kg based on the PiCCO™ measurements. Duration of low CFI was defined by at least one CFI <4.2 min⁻¹ (corresponding to predicted LVEF <40%) over 24 hours. *Significant P-values.

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