Table 3 Comparison of specific interventions employed in trials of bundled goal-directed therapy
From: Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization
Vasopressors | Inotropes | PRBC | Corticosteroids | rhAPC | Appropriate antibiotics | Timely antibiotics | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Study | Control | Bundled care | Control | Bundled care | Control | Bundled care | Control | Bundled care | Control | Bundled care | Control | Bundled care | Control | Bundled care |
ProCESS [24] | 201/456 | 241/439 | 4/456 | 35/439 | 34/456 | 63/439 | 37/456 | 54/439 | 0/456 | 1/439 | 442/456 | 428/439 | NA | NA |
Rivers et al. [2] | 40/133 | 36/130 | 1/133 | 18/130 | 25/133 | 83/130 | NA | NA | NA | NA | 125/133 | 126/130 | 123/133 | 112/130 |
Lin et al. [23] | 81/116 | 80/108 | 16/116 | 13/108 | 43/116 | 39/108 | 25/116 | 32/108 | NA | NA | 107/116 | 102/108 | NA | NA |
El Solh et al. [31] | NA | NA | NA | NA | 11/87 | 12/87 | 14/87 | 83/87 | 2/87 | 11/87 | 73/87 | 84/87 | 79/87 | 83/87 |
Ferrer et al. [33] | 329/854 | 630/1,465 | NA | NA | NA | NA | 311/854 | 611/1,465 | 51/854 | 74/1,465 | 568/854 | 1,009/1,465 | NA | NA |
Jones et al. [30] | 27/79 | 53/77 | 1/79 | 2/77 | 1/79 | 4/77 | 5/79 | 31/77 | 3/79 | 3/77 | NA | NA | NA | NA |
Kortgen et al. [27] | NA | NA | 0/30 | 6/30 | 5/30 | 5/30 | 13/30 | 30/30 | 0/30 | 7/30 | 28/30 | 28/30 | 30/30 | 30/30 |
Lefrant et al. [41] | NA | NA | 40/230 | 20/215 | 24/230 | 34/215 | 91/230 | 122/215 | 0/230 | 4/215 | NA | NA | 141/230 | 145/215 |
Micek et al. [25] | 60/60 | 43/60 | NA | NA | 4/60 | 12/60 | 30/60 | 13/60 | 7/60 | 2/60 | 43/60 | 52/60 | 36/60 | 52/60 |
Na et al. [40] | 171/364 | 135/192 | 144/364 | 78/192 | 17/364 | 4/192 | NA | NA | NA | NA | NA | NA | NA | NA |
Nguyen et al. [29] | 39/77 | 111/253 | 18/77 | 67/253 | 11/77 | 32/253 | 23/77 | 41/253 | 6/77 | 4/253 | NA | NA | 77/77 | 227/253 |
Shapiro et al. [28] | 23/51 | 63/79 | 1/51 | 6/79 | 3/51 | 8/79 | 12/51 | 23/79 | 0/51 | 3/79 | 45/51 | 77/79 | 48/51 | 78/79 |
Trezeciak et al. [26] | 7/16 | 13/22 | 0/16 | 2/22 | 0/16 | 3/22 | 5/16 | 8/22 | 2/16 | 7/22 | NA | NA | NA | NA |
Totals | 978/2206 (44.3) | 1,405/2,825 (49.7) | 225/1,552 (14.5) | 247/1,545 (16.0) | 178/1,699 (10.5) | 299/1,692 (17.7) | 566/2,056 (27.7) | 1,048/2,835 (37.0) | 71/1940 (3.7) | 116/ 2,727 (4.3) | 1,431/1,787 (80.1) | 1,906/2,398 (79.5) | 534/668 (79.9) | 727/854 (85.1) |
P-valuesa | <0.001 | 0.249 | <0.001 | <0.001 | 0.308 | 0.636 | 0.008 | |||||||