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Table 3 Comparison of specific interventions employed in trials of bundled goal-directed therapy

From: Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization

  Vasopressors Inotropes PRBC Corticosteroids rhAPC Appropriate antibiotics Timely antibiotics
Study Control Bundled care Control Bundled care Control Bundled care Control Bundled care Control Bundled care Control Bundled care Control Bundled care
ProCESS [24] 201/456 241/439 4/456 35/439 34/456 63/439 37/456 54/439 0/456 1/439 442/456 428/439 NA NA
Rivers et al. [2] 40/133 36/130 1/133 18/130 25/133 83/130 NA NA NA NA 125/133 126/130 123/133 112/130
Lin et al. [23] 81/116 80/108 16/116 13/108 43/116 39/108 25/116 32/108 NA NA 107/116 102/108 NA NA
El Solh et al. [31] NA NA NA NA 11/87 12/87 14/87 83/87 2/87 11/87 73/87 84/87 79/87 83/87
Ferrer et al. [33] 329/854 630/1,465 NA NA NA NA 311/854 611/1,465 51/854 74/1,465 568/854 1,009/1,465 NA NA
Jones et al. [30] 27/79 53/77 1/79 2/77 1/79 4/77 5/79 31/77 3/79 3/77 NA NA NA NA
Kortgen et al. [27] NA NA 0/30 6/30 5/30 5/30 13/30 30/30 0/30 7/30 28/30 28/30 30/30 30/30
Lefrant et al. [41] NA NA 40/230 20/215 24/230 34/215 91/230 122/215 0/230 4/215 NA NA 141/230 145/215
Micek et al. [25] 60/60 43/60 NA NA 4/60 12/60 30/60 13/60 7/60 2/60 43/60 52/60 36/60 52/60
Na et al. [40] 171/364 135/192 144/364 78/192 17/364 4/192 NA NA NA NA NA NA NA NA
Nguyen et al. [29] 39/77 111/253 18/77 67/253 11/77 32/253 23/77 41/253 6/77 4/253 NA NA 77/77 227/253
Shapiro et al. [28] 23/51 63/79 1/51 6/79 3/51 8/79 12/51 23/79 0/51 3/79 45/51 77/79 48/51 78/79
Trezeciak et al. [26] 7/16 13/22 0/16 2/22 0/16 3/22 5/16 8/22 2/16 7/22 NA NA NA NA
Totals 978/2206 (44.3) 1,405/2,825 (49.7) 225/1,552 (14.5) 247/1,545 (16.0) 178/1,699 (10.5) 299/1,692 (17.7) 566/2,056 (27.7) 1,048/2,835 (37.0) 71/1940 (3.7) 116/ 2,727 (4.3) 1,431/1,787 (80.1) 1,906/2,398 (79.5) 534/668 (79.9) 727/854 (85.1)
P-valuesa <0.001   0.249   <0.001   <0.001   0.308   0.636   0.008  
  1. a P-values for comparison between control and bundled care groups for each intervention. NA, not available; PRBC, packed red blood cells; rhAPC, recombinant human activated protein C.