Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury

Table 5 Summary of the comparison of sighs in this study

	ALIp				ALIexp
	PCV		PSV		PCV		PSV
	NS	Sigh	NS	Sigh	NS	Sigh	NS	Sigh
Ppeak,L (cmH₂0)	→	↓	↓	↓	→	↓	→	↓
Pmean,L (cmH₂0)	→	↓	→	↓	→	↓	→	→
P_0.1	-	-	→	↓	-	-	→	↓
PaO₂ (mmHg)	↑	↑	↑	↑	↑	↑	↑	↑
Alveolar collapse	→	↓	→	↓	→	→	→	↓
Overdistension	-	-	-	-	-	-	-	-
Alveolar-capillary membrane injury	→	↑	→	↑	→	→	→	↑
Lung apoptosis	→	→	→	→	↑	→	→	→
mRNA IL-1β	↑	↓	↑	↓	↓	↑	↓	↑
mRNA IL-6	↑	↓	↑	↓	↓	↑	↓	↑
mRNA PCIII	↑	↓	↑	↓	↓	↑	↓	↑
mRNA pro-caspase-3	↑	↓	↑	↓	↓	↑	↓	↑

The arrows indicate the direction of change of each variable relative to respective NS. ↑: increase in relation to NS; ↓: decrease in relation to NS; →: no changes. ALIp, pulmonary acute lung injury; ALIexp, extrapulmonary acute lung injury; PCV, pressure-controlled ventilation; PSV, pressure support ventilation; NS, non-sigh; Ppeak,L, transpulmonary peak pressure; Pmean,L, transpulmonary mean pressure; P0.1, driving pressure; PaO₂, mmHg, arterial oxygen partial pressure; mRNA IL-1β, mRNA interleukin (IL)-1 β, mRNA IL-6, mRNA interleukin (IL)-6, mRNA PCIII, mRNA type III procollagen.

ISSN: 1364-8535