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Table 5 Practical indications, listed in order of importance, when therapeutic drug monitoring of voriconazole might be useful

From: How to manage aspergillosis in non-neutropenic intensive care unit patients

Clinical situation

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Suspected treatment failure

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Suspected suboptimal dosing - for example, due to interaction with other drugs such as phenytoin, in children or in cerebral infections

Change in the administration of the drug from intravenous to oral routea

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Suspected suboptimal absorption

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Suspected non-compliance

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Suspected neurologic toxicity possibly related to overdosing

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Suspected other toxicity possibly related to overdosing

  1. aAs long as the patient is critical, intravenous therapy is preferred in order to avoid problems with absorption.
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Critical Care

ISSN: 1364-8535