- Paper Report
- Open Access
Hyperchloraemic acidosis and outcome
- Richard Venn1
© Biomed Central Ltd 2001
- Received: 23 October 2001
- Published: 5 December 2001
- Abdominal aneurysm repair
- hyperchloraemic acidosis
Hyperchloraemic acidosis is a consequence of infusions of large quantities of chloride-containing solutions, such as 0.9% normal saline [NS], although there is no evidence that this influences outcome. This study compared the outcomes of patients undergoing abdominal aortic aneurysm repair who received NS with those given lactated Ringer's (LR) solutions intraoperatively.
The NS group received statistically more bicarbonate and platelets, and urine output was greater. There were no differences in other outcome variables.
In a randomised double blind study, 33 patients received NS and 33 LR. Outcome measures included the amount of bicarbonate infused (given if base excess <-5), the amount of blood products used, the duration of ventilation, the length of ICU and hospital stay, and the rate of complications.
Hood VL, Tannen RL: Protection of acid-base balance by pH regulation of acid production.
N Engl J Med 1998, 339:819-826.
See also the associated editorial:
O'Connor, Roizen MF: Lactate versus Chloride: Which is better?
Anesth Analg 2001, 93:809-810.
And the related article:
Wilkes NJ, Woolf R, Mutch M, Mallet SV, Peachey T, Stephens R, Mythen MG: The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical paptients.