- Paper Report
- Open Access
Transfusing prior to extubation
- Jason Ham1
© Biomed Central Ltd 2001
- Received: 17 July 2001
- Published: 4 December 2001
- artificial respiration
- red blood cell transfusion
It is believed that in ventilated patients, anemia that results in decreased oxygen carrying capacity can slow respiratory recovery. This study compared restrictive and liberal transfusion practices in ventilated patients and studied the duration of ventilation, time to successful extubation (weaning), and complications.
There were no statistically significant differences in length of ventilation or time to wean between the two groups after adjusting for confounding factors. Multiple organ dysfunction (MOD) score and mortality increased slightly in the liberal strategy group. Also more complications were noted in the liberal strategy group, including pulmonary edema and myocardial infarction.
Prospective randomized trial of 713 ventilated patients who were part of a larger study (Transfusion Requirements in Critical Care). Patients were randomized to receive transfusions with a hemoglobin concentration of either 7-9 g/dl (restrictive strategy) or 10-12 g/dl (liberal strategy). Confounding variables were forced into a Cox model.
- Hebert PC, Blajchman MA, Cook DJ, Yetisir E, Wells G, Marshall J, Schweitzer I and the Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group : Do blood transfusions improve outcomes relted to mechanical intervention. Chest. 2001, 119: 1850-1857.PubMedView ArticleGoogle Scholar