- Paper Report
- Open Access
Does head elevation decreases cerebral blood flow?
- Naresh Ramakrishnan1
© Current Science Ltd 2000
- Published: 31 May 2000
- Cerebral blood flow
- cerebral perfusion pressure
- head position
- intracranial pressure
- jugular bulb pressure
Head elevation as a treatment to lower ICP in patients with intracranial hypertension has been challenged, as with head elevation both ICP and cerebral perfusion pressure (CPP) have been shown to fall. Changes in CBF however have not been quantified. Hence the rationale of this study to clarify the changes in cerebrovascular hemodynamics with head elevation.
Prospective, observational study in 37 adult patients with coma due to severe intracranial lesions.
The effect of 0o, 15o, 30o and 45o head elevation on CBF, CPP, ICP and arteriovenous pressure gradient were studied. The angles were measured using a goniometer
All patients were mechanically ventilated, sedated and paralyzed. The mean Glasgow coma scale was 6 (range 3-11).
CBF was measured using the thermodilution method.
ICP was measured by catheter inserted into the frontal horn of the lateral ventricle
Jugular catheters were inserted ipsilaterally into the vein on the side of the unilateral hemispheric lesion or on the right side in case of bihemispheric lesions.
With head elevation from 0o to 45o, CBF decreased from 46.3 ± 4.8 to 28.7 ± 2.3 mL/min/100g (P < 0.01); CPP remained stable up to 30o and decreased from 62 ± 3 to 57 ± 4 mmHg between 30o and 45o (P < 0.05) and ICP decreased from 25 ± 2 to 14 ± 1 mmHg between 0o to 30o (P < 0.01) and increased from 14 ± 1 to 16 ± 2 (P < 0.05) between 30o and 45o.On multiple logistic regression analysis using a mathematical model, and even correcting for a calculated CPP, the CBF decreased by 0.15 mL/min/100g /10 head end elevation suggesting despite anything there was truly an independent decrease in blood flow.
Melot C et al: Estimation of cerebral bloodflow at the bedside by continuos jugular thermodilution. J Cereb Blood Flow Metab 1996, 16:1263-1270