- Paper Report
- Open Access
Plasma exchange for toxic epidermal necrolysis
- Richard Venn
© Current Science Ltd 2000
- Published: 12 January 2000
- plasma exchange
- toxic epidermal necrolysis
Toxic epidermal necrolysis (TEN) is a rare skin disorder with a high mortality and is best treated in a burns ICU. Choice of therapy has focused on antibiotics, steroids and plasma exchange (PE), and this study evaluates the effectiveness of PE in one burns ICU.
Retrospective analysis of the effectiveness of PE in the treatment of TEN.
The outcome of eight patients treated with plasmapheresis for TEN over a 10 year period at the authors' ICU was compared to that found in two previous studies where PE was not utilised. (Khoo et al, Burns 1996, 4:275-278, Yarbrough et al, J Burn Care Rehabil 1996, 17:30-33) A median of six (1-8) PEs was given at an interval of 1-3 days.
Mean time from onset of TEN to complete re-epithelialisation was 27 days, which was longer than in the two previous studies where PE was not used. Mortality was similar in all studies.