Open Access

Review: NSAIDs

  • Richard Venn
Critical Care19991:803

Published: 1 July 1999


Adverse effects epidemiology gastrointestinal NSAIDs prostaglandins


A very comprehensive review of the epidemiology, risk factors, pathogenesis and management of non-steroidal anti-inflammatory drug (NSAID)-induced gastric injury.

An important topic for all hospital clinicians since the mortality rate of in-patients suffering from a gastrointestinal bleed as a result of NSAIDs is 5-10%.

Recommendations are discussed for the prevention and treatment of NSAID-induced gastric injury and it is noted that proton pump inhibitors appear to play a prominent role.


  1. Wolfe MM, Lichtenstein DR, Singh G: Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. N Engl J Med. 1999, 340: 1888-1899.PubMedView ArticleGoogle Scholar


© Current Science Ltd 1999