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Review: NSAIDs


A very comprehensive review of the epidemiology, risk factors, pathogenesis and management of non-steroidal anti-inflammatory drug (NSAID)-induced gastric injury.

An important topic for all hospital clinicians since the mortality rate of in-patients suffering from a gastrointestinal bleed as a result of NSAIDs is 5-10%.

Recommendations are discussed for the prevention and treatment of NSAID-induced gastric injury and it is noted that proton pump inhibitors appear to play a prominent role.


  1. Wolfe MM, Lichtenstein DR, Singh G: Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. N Engl J Med. 1999, 340: 1888-1899.

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Venn, R. Review: NSAIDs . Crit Care 1, 803 (1999).

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