Skip to main content

Archived Comments for: Heparin-induced thrombocytopenia in the ICU: an overview

Back to article

  1. Immunologic properties of heparin congeners

    Heikki Savolainen, Dept. of Occup. safety & hlth., Tampere, Finland

    25 March 2011

    Dear Editor,

    The excellent review summarizes the salient points of heparin-induced thrombocytopenia (1). The immnunological features seem to include the circumstance that heparan sulfate (2) ,and thus heparin, may act as "docking" substrate for properdin, an alternate complement component.

    The skin keratinocyte CD-44, i.e. epican, is also a heparan sulfate proteoglycan so that skin lesions associated with heparan could be caused by an analogous mechanism.

    1 Sakr Y. Heparin-induced thrombocytopenia in the ICU: an overview. Critical Care 2011; 15: 211

    2 Zaferani A, et al. Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease. J biol Chem 2011; 286: 5423

    3 Schindewolf M, et al. Incidence and causes of heparin-induced skin lesions. Can med Assoc J 2009; 181: 477

    Competing interests