High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome

Table 1 Clinical characteristics of the studying populations

Variables	Spontaneous breathing controls	Ventilated controls	ARDS patients	P-value
Number of subjects	12	10	52
Age (years, mean ± SD)	59 ± 13	58 ± 14	58 ± 17	0.98
Male sex (n, %)	8 (61)	6 (60)	39 (75)	0.78
SAPS II (mean ± SD)	-	48 ± 13	47 ± 14	0.91
SOFA score (median (IQR))	-	7 (7 to 11)	10 (7 to 12)	0.11
Admission category (n, %)	-			0.28
Medical		10 (100)	42 (80)
Surgical		0 (0)	10 (20)
Direct lung injury (n, %)	-	-	47 (90)	-
Cause of ARDS (n, %)				-
Pneumonia	-	-	38 (73)
Aspiration	-	-	6 (12)
Lung contusion	-	-	3 (6)
Extra pulmonary sepsis	-	-	5 (9)
Reason for ICU hospitalization (n, %)	-		-
Coma		4 (40)		-
Self-poisoning		3 (30)
CNS infections		2 (20)
Epilepsy		1 (10)
LISS at inclusion (median (IQR))	-	0.75 (0.44 to 1)	3 (2.5 to 3.25)	<0.001
Septic shock at inclusion (n, %)	-	6 (60)	43 (83)	0.44
Days under mechanical ventilation before inclusion (median (IQR))	-	2 (0 to 7)	1 (0 to 1)	0.14

ARDS, acute respiratory distress syndrome; CNS, central nervous system; IQR, interquartile range; LISS, lung injury severity score; SAPS II, Simplified acute physiology score II; SD, standard deviation; SOFA score, Sequential Organ Failure Assessment score.
Septic shock was defined as a systolic blood pressure of ≤ 90 mm Hg, despite adequate volume expansion requiring the use of vasopressor agents; P-values compare ventilated controls and ARDS patients.

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