Figure 3
From: Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia
Western blots of lysates of PBMCs of patients with sepsis and of volunteers with endotoxemia. Blots show that cleaved caspase-1 is lost in sepsis. (A) one healthy control and one patient with sepsis (data representative of five sepsis patients tested); (B) quantitative assessment of blots of lysates of PBMCs for four healthy volunteers and for five patients with sepsis; (C) Western blots of caspase-1 before and two hours after in vivo LPS infusion in one healthy volunteer (representative of four volunteers). (D) IL-1β production by LPS-stimulated PBMCs isolated at t = 0, t = 2 and t = 8 hours after LPS infusion in healthy volunteers.