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Table 1 Specific approaches to treatment of toxic shock syndromes

From: Superantigen antagonist peptides

Strategy

Experimental data

Reference

Clindamycin

Toxin production is switched off at sub-bacteriocidal concentrations of antibiotic.

[5,6]

 

Clindamycin use is associated with reduced mortality compared with historical controls

 

Intravenous immunoglobulin

Immunoglobulin neutralizes streptococcal pyrogenic exotoxins in vitro. IgA and IgM

[7,8,9]

 

supplemented preparations may be superior to pure IgG preparations. Adjunctive therapy

 
 

with intravenous immunoglobulin is associated with improved survival compared with

 
 

historical controls

 

Toxoids of pyrogenic exotoxins

Non-superantigenic mutants of SPEA and SPEC protect rabbits from a toxin challenge

[10,11]

  1. SPEA, Streptococcal pyrogenic exotoxin A; SPEC, streptococcal pyrogenic exotoxin C.
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Critical Care

ISSN: 1364-8535