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Volume 15 Supplement 1

31st International Symposium on Intensive Care and Emergency Medicine

Sulfonated immunoglobulin improves cardiopulmonary functions by promoting IGF-I production in ARDS patients with severe sepsis

Critical Care volume 15, Article number: P418 (2011) Cite this article

Introduction

It has been emphasized that severe sepsis often leads to shock and ARDS in critically ill patients. We reported previously that sulfonated immunoglobulin (sIG) administration significantly inhibited the increase of in lung MPO activities and the increase of pulmonary vascular permeability. In the present study, we examined whether sIG improves not only ARDS but also cardiovascular dysfunction in patients with severe sepsis.

Methods

ARDS patients with severe sepsis were divided into two groups, the sIG administrated group and the polyethylene glycol-treated immunoglobulin (pIG) administrated group. We evaluated them by measuring the value of IGF-1, lactate, PF ratio, cathecholamine index, septic severity score (SSS) and SOFA score.

Results

The serum IGF-1 levels in the sIG group were increased at the seventh day significantly (P < 0.05). PF ratios in the sIG group were increased significantly at the seventh day (P < 0.05). The serum lactate levels and catecholamine index in the sIG group were decreased significantly at the seventh day (P < 0.05). The total score of SSS and SOFA also significantly improved in the sIG group at the seventh day (P < 0.05).

Conclusions

These observations suggest that sIG might improve cardiopulmonary functions by promoting IGF-I production in ARDS patients with severe sepsis.

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Authors and Affiliations

  1. Tokyo Women's Medical University MCE, Tokyo, Japan

    Y Deguchi, H Suga, T Sato & T Nakagawa

  2. Nagoya City University Graduate School of Medical Sciences, Aichi, Japan

    N Harada & K Okajima

Authors
  1. Y Deguchi
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  2. H Suga
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  3. T Sato
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  4. N Harada
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  5. T Nakagawa
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  6. K Okajima
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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Deguchi, Y., Suga, H., Sato, T. et al. Sulfonated immunoglobulin improves cardiopulmonary functions by promoting IGF-I production in ARDS patients with severe sepsis. Crit Care 15 (Suppl 1), P418 (2011). https://doi.org/10.1186/cc9838

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  • DOI: https://doi.org/10.1186/cc9838

Keywords

  • Lactate
  • Catecholamine
  • Severe Sepsis
  • Lactate Level
  • Serum Lactate

Critical Care

ISSN: 1364-8535