Volume 15 Supplement 1
Plasma free cortisol and b-type natriuretic peptide in septic shock
© Sturgess and Venkatesh 2011
Published: 1 March 2011
Previous studies of patients with septic shock have independently demonstrated alterations in plasma concentrations of b-type natriuretic peptide (BNP) and plasma free cortisol (PFC). Previous data suggest that a reciprocal relationship might exist. However, the relationship between these hormones in patients with septic shock is unclear. We sought to compare paired measurement of both BNP and PFC in a preliminary study of septic shock patients.
Twenty-one consecutive adult patients from a tertiary-level, multidisciplinary ICU underwent blood collection within 72 hours of developing septic shock.
Mean ± SD APACHE III score was 80.1 ± 23.8. Hospital mortality was 29%. Log PFC demonstrated positive correlation with log BNP (r = 0.55; P = 0.019). Log PFC also correlated with APACHE III (r = 0.67; P < 0.001) and norepinephrine dose (r = 0.55; P = 0.01). APACHE III (P = 0.001) and norepinephrine dose (P = 0.02) were independent predictors of PFC. A model incorporating both variables explained 68% of variation in PFC (R2 = 0.682).
This preliminary study of patients with septic shock demonstrates a modest positive correlation between PFC and BNP concentration. The APACHE III score and norepinephrine dose were independent predictors of PFC.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.