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  • Poster presentation
  • Open Access

Heart rate variability during infusion of dexmedetomidine

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  • 1,
  • 1,
  • 1 and
  • 1
Critical Care201115 (Suppl 1) :P352

  • Published:


  • Heart Rate
  • Heart Rate Variability
  • Continuous Infusion
  • Sympathetic Nerve System
  • Sympathetic Nerve


Dexmedetomidine is an α2-agonist, used for sedation in the ICU, although much remains to be learned about the effects on the autonomic nervous function. We therefore investigated them in the real-time monitoring of heart rate variabilities.


From May through November 2010, 20 patients were selected if they were treated on total mechanical ventilatory support and they were treated with continuous infusion of dexmedetomidine in our ICU. The exclusion cases were with arrhythmia or pacemaker or other treatment during the measure time. Heart rate (HR) variability analysis was recorded using the MemCalc system (MemCalc/Tonam16C; Suwa Trust, Tokyo, Japan). The spectral bands were 0.04 to 0.15 Hz (low frequency (LF)), 0.15 to 0.40 (high frequency (HF)) and others. The HF component was an indicator of sympathetic balance, and LF/HF was that of parasympathetic balance. We measured the HR, CV-RR, HF, LF/HF, systemic blood pressure (SBP), CV-SBP, SBP-HF and SBP-LF/HF. The CV-RR was SD of RR intervals, and the CV-SBP was SD of systemic blood pressure. We compared them between before and after 30 minutes administration of dexmedetomidine. The Wilcoxon signed-ranks test was used to compare the differences. P < 0.05 was considered statistically significant.


The HR was significantly decreased (P = 0.017), and the CV-RR was in a tendency of decrease (P = 0.085). Although the SBP was not significantly changed, the CV-SBP was significantly decreased (P = 0.038). Other parameters (HF, LF/HF, SBP-HF and SBP-LF/HF) were not significantly changed.


We investigated the autonomic nervous functions in 20 patients treated with dexmedetomidine. The HR and the CV-SBP were significantly decreased. Dexmedetomidine was affected with depression of sympathetic nerve system to the HR, the CV-RR and CV-SBP.

Authors’ Affiliations

Kagoshima University Hospital, Kagoshima, Japan


  1. Hogue CW Jr, Talke P, Stein PK, et al.: Autonomic nervous system responses during sedative infusions of dexmedetomidine. Anesthesiology 2002, 97: 592-598. 10.1097/00000542-200209000-00012View ArticlePubMedGoogle Scholar
  2. Papaioannou VE, Dragoumanis C, Theodorou V, et al.: Relation of heart rate variability to serum levels of C-reactive protein, interleukin 6, and 10 in patients with sepsis and septic shock. J Crit Care 2009, 24: 625.e1-625.e7. 10.1016/j.jcrc.2008.11.010View ArticleGoogle Scholar


© Imabayashi et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.