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  • Poster presentation
  • Open Access

Dead space fraction indicates the titration of optimal positive end-expiratory pressure after recruitment in acute respiratory distress syndrome

  • 1,
  • 1 and
  • 1
Critical Care201115 (Suppl 1) :P203

  • Published:


  • Public Health
  • Emergency Medicine
  • Respiratory Distress
  • Respiratory Distress Syndrome
  • Distress Syndrome


The objective of this study is to evaluate the value of dead space fraction (VD/VT) as a method for indicating the optimal PEEP titration.


Twenty-three patients with ARDS were enrolled in the study. After lung recruitment using sustained inflation (SI), the optimal PEEP was respectively titrated by the optimal oxygenation, the maximum static pulmonary compliance (Cst), and the lowest VD/VT. The influence of these methods on oxygenation, Cst, VD/VT and FRC were observed.


The PEEP level titrated by the lowest VD/VT (10.1 ± 2.8 cmH2O) had no significant difference from the PEEP level titrated by the maximum Cst (11.3 ± 2.5 cmH2O) (P > 0.05). However, the PEEP level titrated by the lowest VD/VT was significantly lower than that determined by optimal oxygenation (P < 0.05). The oxygenation at the PEEP titrated by VD/VT was significantly lower than the optimal oxygenation, but no significant difference in PaO2/FiO2 was observed between the PEEP titrated by the lowest VD/VT and the maximum Cst. Additionally, the VD/VT and the FRC at the PEEP chosen by the three methods also had no significant difference.


The lowest VD/VT could be one of the methods to choose the optimal PEEP in ARDS patients.

Authors’ Affiliations

Zhong-Da Hospital and College of Southeast University, Nanjing, China


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© Yang et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.