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  • Poster presentation
  • Open Access

Pharmacological randomized controlled trials in acute respiratory distress syndrome mortality

  • 1,
  • 2 and
  • 3
Critical Care201115 (Suppl 1) :P189

https://doi.org/10.1186/cc9609

  • Published:

Keywords

  • Nitric Oxide
  • Prostaglandin
  • Lung Injury
  • Pharmacological Treatment
  • Methylprednisolone

Introduction

Acute lung injury and acute respiratory distress syndrome are common conditions encountered in the ICU. Whether mortality has decreased over time or not, they are still many unanswered questions about the impact of pharmacological treatment on ALI/ARDS mortality.

Methods

The objectives were to perform a review of the literature in search of the randomized control trials that asses the pharmacological impact in ALI/ARDS on all-cause mortality. We included all RCTs of pharmacological treatments in ALI/ARDS that had an impact in mortality in adults. We excluded RCTs that included patients <18 years old and animals. We also excluded trials that tested fluid therapy, mechanical ventilation, nonpharmacological treatments, antibiotics and reviews. No date or language restriction was applied.

Results

We included 37 RCTs involving 6,303 patients in different ALI/ARDS treatment modalities: steroids (n = 271), enteral nutrition (n = 411), surfactant (n = 1,754), nitric oxide (n = 1,342), APC (n = 75), muscle relaxants (n = 340), prostaglandins (n = 550), NAC (n = 127), silvelastat (n = 492), rPAF-HD (n = 127) lisofylline (n = 235), rFVIIa antagonist (n = 214), OTZ (n = 215) and verapamile-procaine compound (n = 150).

Conclusions

Only steroid treatment (methylprednisolone) and nutritional therapy (EPA + GLA + antioxidants) showed a trend towards reduced mortality. Other treatments were associated with reduced morbidity. However, many empirical treatments are still used in day-to-day practice.

Authors’ Affiliations

(1)
Fundacion Abood Shaio, Bogota, Colombia
(2)
Hospital Valladolid, Spain
(3)
Erasme Hopital, Brussels, Belgium

References

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  2. Phua J, Ferguson ND, et al.: Am J Respir Crit Care Med. 2010, in press.Google Scholar
  3. Tang , et al.: Crit Care Med. 2009, 37: 1594-1603.View ArticlePubMedGoogle Scholar
  4. Adhikari NKJ, Burns KEA, Meade MO, Ratnapalan M: Cochrane Database Syst Rev. 10: CD004477.Google Scholar

Copyright

© Santacruz et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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