Skip to main content

Relation between mortality rate, duration of hospitalization and levels of TNFα, IL-6 and catalase at admission of cases to the emergency department with COPD attack

Introduction

The aim of the study was to investigate the relation between the mortality rate, the hospitalization period in the emergency department or ICU and the obtained levels of TNFα, IL-6 and catalase before they underwent attack treatment at admission of the cases applying to the emergency department with COPD attack.

Methods

The cases diagnosed with COPD before and who applied to the emergency department with COPD attack were included in the study. Venous blood samples were obtained to evaluate the levels of TNFα, IL-6, catalase, leucocyte, sedimentation and CRP when the cases applied to the emergency department. Their hospitalization in the service or ICU, the follow-up period in mechanical ventilation and leaving hospital (dead or discharged) were followed. The mean levels of TNFα, IL-6, catalase, leucocyte, sedimentation and CRP values were compared with the average period of hospitalization in the service or ICU and with each other. The Mann-Whitney U test and chi-square test were used as nonparametric tests. P ≤ 0.05 values were regarded as significant.

Results

All of the cases that died (n = 7) were followed in intensive care, they underwent invasive mechanical ventilation treatment and their mean hospitalization period was 25 days. The cases discharged (n = 80) were all followed in the service and their average hospitalization duration was 6.2 days. Non-invasive mechanical ventilation was applied to 12 of these cases. Of the dead cases, the mean leukocyte value was 12.665, sedimentation 29.68, CRP 49.7, TNFα 27.3, IL-6 32 and catalase was 81. Of the cases discharged, the mean leukocyte value was 8.200, sedimentation 19.0, CRP 49.7, TNFα 29.3, IL 13.6 and catalase was 85.9. The mean value of leukocyte, sedimentation, CRP and IL-6 of the dead cases were significantly higher than those of the cases in the discharged group (P = 0.040, 0.038, 0.02, 0.017, respectively).

Conclusions

A high level of leukocyte, sedimentation, CRP values and low IL-6 values at the admission of cases with COPD attack to the emergency department may indicate the requirement to follow in the ICU and treatment with mechanical ventilation, and a high mortality rate.

Author information

Affiliations

Authors

Corresponding author

Correspondence to A Bayır.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Bayır, A., Büyükünaldı, P., Kıyıcı, A. et al. Relation between mortality rate, duration of hospitalization and levels of TNFα, IL-6 and catalase at admission of cases to the emergency department with COPD attack. Crit Care 15, P186 (2011). https://doi.org/10.1186/cc9606

Download citation

Keywords

  • Mortality Rate
  • Emergency Department
  • Mechanical Ventilation
  • Catalase
  • Venous Blood