Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis

Table 1 Summary of included studies

Study (ref)	Year	Country	Number of patients		Age	Lactate method	Cut-off (mmol/L)	Test results
			BM	AM				TP^a	FP	FN	TN
Abro[37]	2008	UAE	86	48	Adult	Enz^d	3.8	85	0	1	48
Kleine[59]	2003	Germany	73	128	Adult	Enz	2.61	73	0	0	128
Schwarz[58]	2000	Germany	16	14	Adult	NR^c	2.1	15	8	1	6
Uduman[57]	2000	UAE	23	42	Children	Enz	NR	22	3	1	39
Cameron[38]	1993	UK	11	9	Children	Enz	4.1	11	0	0	9
Genton[39]	1990	Switzerland	19	28	Adult	Auto^e	4.2	18	0	1	28
Shaltout[40]	1989	Kuwait	14	9	Children	Auto	3	13	0	1	9
Donald[41]	1986	S. Africa	43	23	Children	Enz	2.85	40	0	3	23
Nelson[42]	1986	Sweden	11	28	Children	Enz	2.4	11	3	0	25
Low[43]	1986	Singapore	22	54	Children	Enz	2.78	19	8	3	46
Ruuskanen[12]	1985	Finland	32	30	Children	Enz	3	30	2	2	28
Lester[44]	1985	Denmark	15	15	Child/adult	Enz	4.3	15	0	0	15
Vanprapar[45]	1983	Thailand	22	18	Children	Enz	3.89	20	0	2	18
Mandal[46]	1983	UK	20	59	Children	Enz	3.9	20	5	0	54
Pönkä[47]	1983	Finland	11	27	Child/adult	Enz	3	10	1	1	26
Briem[48]	1983	Sweden	45	102	Child/adult	Enz	3.5	45	4	0	98
Berg[49]	1982	Sweden	18	121	Child/adult	Enz	3	16	9	2	112
Eross[50]	1981	Australia	66	31	Child/adult	Enz	3.9	64	0	2	31
Knight[51]	1981	US	68	20	Children	Enz	3.3	68	3	0	17
Curtis[52]	1981	UK	13	12	Child/adult	Enz	2.8	13	0	0	12
Lannigan[53]	1980	Canada	14	14	Adult	Enz	3.89	13	3	1	11
Gästrin[11]	1979	Sweden	38	17	Child/adult	GL^b	3.5	37	3	1	14
Lauwers[54]	1978	Belgium	35	20	NR^c	GL	3.89	33	0	2	20
Controni[55]	1977	US	55	15	Children	Enz&GL	2.78	53	0	2	15
Bland[56]	1974	US	13	25	Children	Enz	4.44	12	0	1	25

^aTP, true-positive; FP, false-positive; FN, false-negative; TN, true-negative; ^bGL, gas-liquid chromatography; ^cNR, not reported; ^dEnz, Enzymatic; ^eAutomatic analyzer.

ISSN: 1364-8535