Genome-wide transcription profiling of human sepsis: a systematic review

Table 1 Summary of studies characteristics

	Prucha[14]	Tang-1[15, 16]	Ramilo[17]	Tang-2[18]	Talwar[8]	Payen[19]	Cobb[20, 21]	Pachot[22]	Prabhakar[9]	Calvano[10]	Wong[23–26]	Johnson[27, 28]
Aims	Diagnostic prediction	Diagnostic prediction	Diagnostic prediction	Diagnostic prediction	Functional analysis	Prognostic study	Prognostic study	Prognostic study	Functional analysis	Functional analysis	Combined analysis^¥	Functional analysis
Study design	Cross-sectional	Cross-sectional	Cross-sectional	Cross-sectional	Longitudinal	Longitudinal	Longitudinal	Cross-sectional	Longitudinal	Longitudinal	Longitudinal	Longitudinal
Country	Czech Rep..	Australia	U.S.A.	Australia	U.S.A.	France	U.S.A.	France	U.S.A.	U.S.A.	U.S.A.	U.S.A.
Total (n)	12	94	148	70	12	17	176	38	12	14	101	90
Mean Age (yr)	58.9	63.5	3.4	65.5	30	59	35.7	67	(18 to 40)^†	(18 to 40)^†	3.2	44
Clinical setting	Adult ICU	Adult ICU	Pediatric wards	Adult ICU	University clinic	Adult ICU	Adult ICU	Adult ICU	University clinic	University clinic	Pediatric ICU	Trauma ICU
Inclusion criteria	Severe sepsis	Sepsis	Acute infection	Sepsis	Healthy volunteers	Septic shock	Post-trauma	Septic shock	Healthy volunteers	Healthy volunteers	Sepsis	SIRS
Control group	Surgical patients	SIRS patients	Healthy subjects	SIRS patients	Healthy subjects	Subjects at time zero	Non-septic patients	NA	Subjects at time zero	Healthy subjects	Non-septic patients	SIRS patients

SIRS denotes systemic inflammatory response syndrome. ICU denotes intensive care unit. NA denotes not applicable.
^†Mean age not available. ^¥Both functional analysis and diagnostic prediction.

ISSN: 1364-8535