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Table 2 Comparison of metformin-associated lactic acidosis and very severe lactic acidosis of other origin (pH < 7.0)

From: Outcome of severe lactic acidosis associated with metformin accumulation

  All patients with pH < 7.0 (n= 41) MALA (n= 10) LAOO (n= 31)
Age, years 64 ± 13 66 ± 9 64 ± 14
Male gender 19 (46%) 4 (40%) 15 (48%)
SAPS II 84 ± 18 88 ± 23 83 ± 16
SOFA score 14.0 ± 2.9 14.3 ± 1.4 13.8 ± 3.4
   Respiratory 2.7 ± 1.0 2.7 ± 0.9 2.8 ± 1.0
   Renal 3.0 ± 1.1 4.0 ± 0.0 2.6 ± 1.1a
   Hepatic 0.5 ± 0.8 0.3 ± 0.7 0.6 ± 0.9
   Cardiovascular 3.6 ± 1.2 4.0 ± 0.0 3.4 ± 1.4
   Hematologic 0.8 ± 1.1 0.5 ± 0.8 0.9 ± 1.2
   Neurologic 3.3 ± 1.2 2.8 ± 1.5 3.5 ± 1.1
Lactate, mmol/L 18.1 ± 6.5 18.7 ± 5.3 17.9 ± 6.9
pH 6.83 ± 0.12 6.75 ± 0.13 6.86 ± 0.11a
Bicarbonate, mmol/L 9.0 ± 4.8 4.4 ± 2.4 10.5 ± 4.5a
Creatinine, μmol/L 529 ± 392 796 ± 324 195 ± 91a
Survival 4 (10%) 5 (50%) 0 (0%)a
  1. Values are presented as mean ± standard deviation or as number (percentage). Comparison with metformin-associated lactic acidosis (MALA): aP < 0.01. LAOO, lactic acidosis of other origin; SAPS II, Simplified Acute Physiology Score II; SOFA, Sequential Organ Failure Assessment.