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Figure 2 | Critical Care

Figure 2

From: PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction

Figure 2

Anti-PD-L1 antibody administration protects mice from sepsis-induced lethality. (A) Anti-PD-L1 antibody pretreatment protected mice from CLP. CLP mice were given 50 μg anti-PD-L1 antibody (n = 18), 50 μg isotype control antibody (n = 12) or 0.2 mL saline intraperitoneally 24 h before CLP surgery. (B) Effect of intraperitoneal anti-PD-L1 antibody treatment given 3 h after CLP. CLP mice were given 50 μg anti-PD-L1 antibody (n = 18), 50 μg isotype control antibody (n = 12) or 0.2 mL saline (n = 12) intraperitoneally 3 h after CLP. Survival was monitored for eight days. Data are shown as the survival percent of animals. *P <0.05.

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Critical Care

ISSN: 1364-8535