Table 1 Global hemodynamics

CVP (mmHg)

Sham

7 ± 1

13 ± 2^#

12 ± 1^#

11 ± 1^#

10 ± 1^#

10 ± 1^#

Control

6 ± 1

9 ± 1^#

11 ± 1^#

13 ± 1^#

14 ± 1^#†

15 ± 1^#†

rhAPC

5 ± 1

10 ± 1^#

11 ± 1^#

11 ± 1^#

13 ± 1^#

13 ± 2^#

MPAP (mmHg)

Sham

23 ± 1

26 ± 1

27 ± 1

26 ± 1

26 ± 1

27 ± 1^#

Control

21 ± 1

26 ± 2^#

31 ± 2^#†

28 ± 1^#

30 ± 1^#

33 ± 1^#†

rhAPC

20 ± 1

25 ± 1^#

25 ± 1^#*

27 ± 2^#

30 ± 2^#

28 ± 2^#*

PAOP (mmHg)

Sham

11 ± 1

14 ± 1^#

15 ± 1^#

14 ± 1^#

16 ± 1^#

14 ± 1^#

Control

10 ± 1

15 ± 1^#

16 ± 1^#

17 ± 1^#

17 ± 1^#

18 ± 1^#†

rhAPC

11 ± 1

16 ± 1^#

16 ± 1^#

17 ± 1^#

17 ± 1^#

16 ± 1^#*

LAP (mmHg)

Sham

7 ± 0

9 ± 1^#

10 ± 1^#

9 ± 1^#

9 ± 1^#

9 ± 1^#

Control

7 ± 1

11 ± 1^#

15 ± 2^#†

15 ± 1^#†

17 ± 1^†

19 ± 1^#†

rhAPC

9 ± 2

9 ± 1

11 ± 1*

13 ± 1^#†

15 ± 1^#†

14 ± 2^#†*

CI (l/min/m²)

Sham

5.6 ± 0.1

5.3 ± 0.3

5.1 ± 0.1

4.8 ± 0.1

4.8 ± 0.1

4.6 ± 0.1

Control

5.3 ± 0.3

5.8 ± 0.5

6.2 ± 0.4^#†

6.5 ± 0.3^#†

6.9 ± 0.3^#†

8.7 ± 0.4^#†

rhAPC

5.0 ± 0.2

5.2 ± 0.4

5.5 ± 0.4

5.7 ± 0.3^†*

6.1 ± 0.2^#†*

6.2 ± 0.2^#†*

SVRI (dyne s/cm⁵/m²)

Sham

1289 ± 87

1374 ± 133

1402 ± 103

1502 ± 64

1576 ± 79

1599 ± 96

Control

1419 ± 59

1224 ± 92

1128 ± 85^#

740 ± 50^#†

632 ± 52^#†

502 ± 42^#†

rhAPC

1464 ± 79

1364 ± 187

1334 ± 188

1111 ± 64^#†*

968 ± 51^#†*

934 ± 41^#†*

PaO₂:FiO₂ ratio

Sham

506 ± 10

471 ± 11

490 ± 18

492 ± 17

498 ± 16

491 ± 19

Control

521 ± 19

202 ± 36^#†

144 ± 26^#†

72 ± 5^#†

72 ± 7^#†

74 ± 6^#†

rhAPC

541 ± 10

245 ± 56^#†

176 ± 39^#†

151 ± 24^#†*

134 ± 22^#†*

118 ± 17^#†

PaCO₂ (mmHg)

Sham

32 ± 1

29 ± 1

26 ± 1^#

25 ± 1^#

23 ± 2^#

24 ± 1^#

Control

37 ± 2

29 ± 3^#

27 ± 3^#

28 ± 2^#

29 ± 0^#

29 ± 2^#

rhAPC

36 ± 0

25 ± 3^#

27 ± 2^#

25 ± 2^#

27 ± 2^#

27 ± 4^#

apH (-log₁₀[H⁺])

Sham

7.469 ± 0.012

7.542 ± 0.027^#

7.537 ± 0.014^#

7.558 ± 0.019^#

7.583 ± 0.015^#

7.548 ± 0.026^#

Control

7.449 ± 0.014

7.577 ± 0.031^#

7.564 ± 0.025^#

7.525 ± 0.012^#

7.465 ± 0.031^†

7.437 ± 0.027^†

rhAPC

7.470 ± 0.010

7.622 ± 0.026^#†

7.590 ± 0.018^#

7.556 ± 0.016^#

7.509 ± 0.024^†

7.480 ± 0.043^†

DO₂I (ml/min/m²)

Sham

607 ± 33

651 ± 49

648 ± 57

567 ± 48

565 ± 38

551 ± 41

Control

580 ± 70

663 ± 58

719 ± 62#

709 ± 27^#

726 ± 67^#

984 ± 82^#†

rhAPC

624 ± 32

638 ± 43

690 ± 51

644 ± 56

650 ± 40

666 ± 37^#*

VO₂I (ml/min/m²)

Sham

209 ± 21

198 ± 26

183 ± 21

170 ± 21

195 ± 31

165 ± 23

Control

242 ± 24

220 ± 30

231 ± 30

215 ± 35

178 ± 29

274 ± 41

rhAPC

197 ± 16

244 ± 24

227 ± 24

193 ± 31

186 ± 25

253 ± 39

Temperature (°C)

Sham

39.0 ± 0.1

39.5 ± 0.1

39.5 ± 0.1

39.2 ± 0.2

39.1 ± 0.1

39.2 ± 0.1

Control

39.1 ± 0.1

40.2 ± 0.2^#†

40.5 ± 0.2^#†

40.4 ± 0.2^#†

40.1 ± 0.2^#†

40.1 ± 0.3^#†

rhAPC

39.3 ± 0.1

40.0 ± 0.2^#†

40.5 ± 0.2^#†

40.5 ± 0.1^#†

40.4 ± 0.2^#†

40.4 ± 0.1^#†

Hematocrit (%)

Sham

25.2 ± 0.8

26.2 ± 1.2

26.0 ± 1.6

25.0 ± 1.3

24.7 ± 1.0

24.7 ± 1.0

Control

25.3 ± 1.0

27.5 ± 0.9^#

28.3 ± 0.8^#

29.7 ± 0.9^#†

28.8 ± 1.2^#

28.9 ± 0.7^#†

rhAPC

28.2 ± 0.9

27.7 ± 1.1

29.7 ± 1.3

28.3 ± 0.9^†

28.3 ± 1.0

27.2 ± 0.7^†

Plasma NO_x (μM)

Sham

5.0 ± 0.6

5.4 ± 0.6

5.4 ± 0.8

5.0 ± 0.9

5.8 ± 0.7

6.0 ± 0.7

Control

5.2 ± 0.5

7.1 ± 0.8^#

7.9 ± 0.8^#†

9.0 ± 1.2^#†

9.8 ± 1.1^#†

10.5 ± 1.1^#†

rhAPC

4.6 ± 0.6

7.8 ± 0.6^#

9.4 ± 0.5^#†

9.6 ± 1.1^#†

9.5 ± 1.1^#†

8.9 ± 0.8^#†

Plasma Onc (mmHg)

Sham

21.9 ± 0.4

20.9 ± 0.7

20.2 ± 0.9

20.8 ± 0.6

22.1 ± 0.5

22.5 ± 0.7

Control

22.7 ± 0.9

19.5 ± 0.4^#

16.2 ± 0.7^#†

14.4 ± 0.7^#†

12.5 ± 0.8^#†

10.9 ± 1.0^#†

rhAPC

24.3 ± 0.4

22.7 ± 0.3*

21.0 ± 0.3^#*

18.3 ± 0.7^#†*

15.9 ± 1.3^#†*

14.7 ± 1.5^#†*