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Table 6 Serum cytokine levels at admission and 3 days later in nvA(H1N1)-ARDS group survivors versus nonsurvivors

From: Clinical aspects and cytokine response in severe H1N1 influenza A virus infection

Cytokine (pg/ml) P1a P2b
  Survivors Nonsurvivors P value c Survivors Nonsurvivors P value c
IL-6 14.76 (9.69 to 21.54) 64.76 (23.17 to 197.4) 0.025 8.73 (7.91 to 11.25) 26.9 (12 to 51.36) 0.005
IL-8 36.95 (16.75 to 41.49) 75.41 (36 to 148.3) 0.07 22.84 (14.6 to 46.86) 61 (17.44 to 89.8) 0.2
IL-9 10.6 (8.95 to 12.33) 13 (10.4 to 24.7) 0.12 11.3 (8.97 to 12.53) 14.5 (10.1 to 16.8) 0.2
IL-12 10.67 (7.11 to 14.24) 14.24 (10.67 to 17.8) 0.07 14.24 (9.78 to 15.13) 10.67 (10 to 14.24) 0.2
IL-15 4.55 (4.025 to 5.575) 10.6 (6.18 to 14.3) 0.006 4.7 (3.6 to 5.325) 10.4 (5.3 to 18.4) 0.012
IL-17 0.98 (0.323 to 1.146) 0.323 (0.323 to 4.373) 0.8 0.323 (0.323 to 0.323) 1.2 (0.323 to 1.645) 0.026
IP-10 57.26 (21.05 to 380.7) 99.87 (8.055 to 199.6) 0.9 29.67 (9.56 to 42.87) 40.2 (6.6 to 93.71) 0.5
TNFα 4.15 (3.262 to 6.964) 4.15 (0.596 to 11.89) 0.9 0.596 (0.596 to 1.485) 0.596 (0.596 to 2.12) 0.4
IFNγ 3.4 (2.965 to 3.925) 5.43 (3.4 to 5.819) 0.19 3.4 (2.965 to 3.925) 3.7 (3 to 3.82) 0.5
  1. Data presented as median (interquartile range). IP-10, interferon-inductible protein-10; nvA(H1N1), novel A(H1N1) virus. P1aSerum cytokine levels at admission. P2bSerum cytokines levels 3 days after admission. c comparison between survivors and nonsurvivors (Mann-Whitney U test).