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Table 1 Description of the different groups and their activation protocol

From: Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation, shear stress and endothelial injury

Group Activation Description
HUVEC-/PMN- HUVEC 0 ng/ml LPS Control (non-inflamed tissue)
  + PMN 0 ng/ml LPS  
HUVEC++/PMN- HUVEC 100 ng/ml LPS Maximal local inflammation
  + PMN 0 ng/ml LPS  
HUVEC++/PMN ++ HUVEC 100 ng/ml LPS Maximal systemical inflammation in the hyper-inflammatory stage of sepsis
  + PMN 100 ng/ml LPS  
HUVEC+/PMN- HUVEC 10 ng/ml LPS Submaximal local inflammation
  + PMN 0 ng/ml LPS  
HUVEC+/PMN + HUVEC 10 ng/ml LPS Submaximal systemical inflammation in the hypo-inflammatory stage of sepsis
  + PMN 10 ng/ml LPS  
HUVEC++/PMN++/PLT HUVEC 100 ng/ml LPS Maximal systemical inflammation and endothelial damage in the hyper-inflammatory stage of sepsis
  + PMN 100 ng/ml LPS  
HUVEC+/PMN+/PLT HUVEC 10 ng/ml LPS Submaximal systemical inflammation and endothelial damage in the hypo-inflammatory stage of sepsis
  + PMN 10 ng/ml LPS  
  1. HUVEC, human umbilical venous endothelial cells; PMN, polymorphonuclear neutrophils; PLT, platelets; LPS, lipopolysaccharide.