Table 1 Activities of C1 inhibitor
From: Bench-to-bedside review: The role of C1-esterase inhibitor in sepsis and other critical illnesses
Protease inhibition | Â |
|---|---|
   Complement system | C1r, C1 s, MASP2 |
   Plasma kallikrein-kinin system | Plasma kallikrein, factor XII |
   Fibrinolytic system | Plasmin, tissue plasminogen activator |
   Coagulation system | Factor XI, thrombin |
Interactions with endogenous proteins | Â |
   Complement system | C3b |
   Extracellular matrix | Type IV collagen, laminin, entactin, 3 fibrin |
Interactions with cells | Â |
   Circulating cells | Neutrophils, macrophages |
   Vascular cells | Endothelial cells (E and P selectins) |
Interactions with infectious agents | Â |
   Endotoxin | Escherichia coli 011:B4, E. Coli 0127:B5, E. Coli 055:B5, E. Coli K-235, Salmonella typhimurium, Salmonella minnesota, Salmonella typhosa |
   Bacteria | Bordetella pertussis, E. coli, Serratia marcescens |
   Parasites | Plasmodium falciparum |