The role of selected biochemical values in graft quality prediction in brain death organ donors
© Current Science Ltd 2000
Published: 21 March 2000
The aim of the study was to evaluate selected biochemical values in brain death kidney donors and to compare these results with number of rejection episodes in recipients.
After institutional approval 35 patients were prospectively studied. According to insult leading to brain injury, patients after brain death diagnosis (angiography) were divided into the two groups: donors with traumatic intracranial hemorrhage (Group D1) and donors with non-traumatic intracranial hemorrhage (Group D2). Blood samples were drawn immediately after brain death diagnosis. Lymphocyte count, CD3, CD4, CD8, CD19, CD56/16, CD25, ALT, AST, immunoglobulins (IgG, IgM, IgA), malondialdehyde, erythrocyte glutathione levels (GSH) and erythrocyte glutathione-peroxidase activity (GPX), selenium, sIL-2R, IL-2, IL-6, IL-8 and TNF-α were measured. Results as mean (SD), *P<0,05.
Selected results are presented in the Table.
Group D1 (n=17)
Group D2 (n=18)
Recipients no rejection
Rejection treated by steroids
Rejection resistant to steroids
GPX (mg/g Hb)
GSH (mg/g Hb)
Serum IL-6 (pg/mL)