Archived Comments for:
Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats
Heikki Savolainen, Dept. of Occup. Safety & Hlth., Tampere, Finland
21 September 2010
Dear Editor,
Hydrogen sulfide is a notorious inhibitor of the cytochrome oxidase activity at the end of the mitochondrial respiratory chain (1). This explains the lethality of the gas exposure accidents and decreased consumption of oxygen in the brain (1).
The elegant work by Ganster et al. (2) shows beneficial effects in the vascular system by a much lower dose. One might ask whether the mechanisms of these are other than the inhibition of oxygen metabolism. Hydrosulfide salts are also very alkaline and it may be asked whether this plays a role in a direct infusion as well.
1 Rafalowska U, Zitting A, Savolainen H. Metabolic changes in rat brain synaptosomes after exposure to sulfide in vivo. Toxicol Lett 1986; 34: 193-200
2 Ganster F, Burban M, de La Bourdonnaye M, et al. Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidarive stress during resuscitated hemorrhagic shock in rats. Critical Care 2010; 14: R165
Critical Care
Mechanism of hydrogen sulfide effects
21 September 2010
Dear Editor,
Hydrogen sulfide is a notorious inhibitor of the cytochrome oxidase activity at the end of the mitochondrial respiratory chain (1). This explains the lethality of the gas exposure accidents and decreased consumption of oxygen in the brain (1).
The elegant work by Ganster et al. (2) shows beneficial effects in the vascular system by a much lower dose. One might ask whether the mechanisms of these are other than the inhibition of oxygen metabolism. Hydrosulfide salts are also very alkaline and it may be asked whether this plays a role in a direct infusion as well.
1 Rafalowska U, Zitting A, Savolainen H. Metabolic changes in rat brain synaptosomes after exposure to sulfide in vivo. Toxicol Lett 1986; 34: 193-200
2 Ganster F, Burban M, de La Bourdonnaye M, et al. Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidarive stress during resuscitated hemorrhagic shock in rats. Critical Care
2010; 14: R165
Competing interests
None