Figure 2
From: Bench-to-bedside review: Hypercapnic acidosis in lung injury - from 'permissive' to 'therapeutic'
Effect of hypercapnic acidosis on lung tissue cytokines in ventilated mice. Effect of 2 hours of normo- and hypercapnic mechanical ventilation on ventilation-induced lung tissue cytokine release using identical ventilator settings. *P <0.05 versus control; +P <0.05, 0.06% CO2 versus 2% CO2 versus 4% CO2. KC, keratinocyte-derived chemokine. This figure is reproduced with permission of the publisher. (Halbertsma FJ, Vaneker M, Pickkers P, et al. Hypercapnic acidosis attenuates the pulmonary innate immune response in ventilated healthy mice. Crit Care Med 2008, 36:2403-2406.).