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Figure 7 | Critical Care

Figure 7

From: Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice

Figure 7

Time-course of plasma cytokines after flagellin administration. Cytokines were quantified by ELISA in plasma at baseline (time 0), at one, three and six hours after 5 μg flagellin, and at one and three hours after 1 μg flagellin in separate groups of mice (n = 5 to 6 mice/group). An early peak (1 h) was noted for TNFα, IL-6 and macrophage-inhibitory protein-2 (MIP-2), whereas IL-1β and soluble triggering receptor expressed on myeloid cells (sTREM-1) steadily increased over six hours. * P < 0.05 versus baseline (analysis of variance followed by Dunnett's test).

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