Hemodynamic criteria |
   Systolic blood pressure (SBP) of less than 90 mm Hg for greater than 30 minutes |
   SBP drop of greater than 30 mm Hg below basal for greater than 30 minutes in patients with hypertension |
   Use of vasopressors and inotropes to keep SBP greater than 90 mm Hg |
   Cardiac index of less than 2.2 L/min per m2 |
   Pulmonary artery occlusion pressure of greater than 15 mm Hg |
Signs of tissue hypoperfusion |
   Pale, cool, and clammy peripheries |
   Prolonged capillary refill times |
   Altered mental status/confusion |
   Oliguria |
   Pulmonary congestion |
   Tachycardia |
   Elevated lactate |
   Mixed venous saturation of less than 65% |