Skip to main content

Advertisement

Table 1 Comparison of SPRINT and retrospective cohort baseline variables with glycemic control and intervention results

From: Organ failure and tight glycemic control in the SPRINT study

  Overall
  Retrospective SPRINT P -value
Total patients 413 371  
Age (years) 64 (53 to 74) 65 (49 to 74) 0.53
% Male 59.1% 63.6% 0.19
APACHE II score 18 (15 to 23) 18 (15 to 24) 0.50
APACHE II risk of death 28.5% (14.2% to 49.7%) 25.7% (13.1% to 49.4%) 0.39
Diabetic history 71 (17.2%) 62 (16.7%) 0.86
LoS median, IQR (days) 3.8 (1.8 to 8.8) 4.1 (1.7 to 10.4) 0.94
Median BG (SD) (mmol/L) 7.2 (2.4) 6.0 (1.5) <0.01
% BG in 4.4-6.1 mmol/L 30.0% 53.9% <0.01
% BG in 4.0-7.0 mmol/L 49.6% 80.1% <0.01
% BG < 2.2 mmol/L 0.2% 0.1% <0.01
Mean insulin rate (U/hour) 1.2 2.8 <0.01
Mean nutrition (kcal/day) 1,599 1,283 <0.01
APACHE III diagnosis      
Operative Num. patients % Num. patients % P-value
   Cardiovascular 99 24% 76 20% 0.24
   Respiratory 10 2% 9 2% 1.00
   Gastrointestinal 53 13% 60 16% 0.18
   Neurological 9 2% 7 2% 0.77
   Trauma 8 2% 14 4% 0.12
   Other (Renal, metabolic, orthopaedic) 4 1% 4 1% 0.88
Non-operative Num. patients % Num. patients % P-value
   Cardiovascular 41 10% 39 11% 0.79
   Respiratory 77 19% 66 18% 0.76
   Gastrointestinal 7 2% 10 3% 0.34
   Neurological 33 8% 20 5% 0.15
   Trauma 29 7% 32 9% 0.40
   Sepsis 29 7% 17 5% 0.15
   Other (Renal, metabolic, orthopaedic) 14 3% 17 5% 0.39
  1. P-values computed using chi-squared and rank-sum tests where appropriate.
  2. APACHE, Acute Physiology and Chronic Health Evaluation; BG, blood glucose (level); IQR, inter-quartile range; LoS, length of stay; SD, standard deviation.