Simvastatin reduced VILI-associated lung hyperpermeability. Human serum albumin (HSA; 1 mg) was injected 90 minutes prior to termination of the experiment. In non-ventilated simvastatin (NV + Simva) or sham (NV) treated mice, and in ventilated and simvastatin (6 h Vent. + Simva) or sham (6 h Vent.) treated mice, HSA levels in plasma and BAL were determined. Simvastatin treatment reduced VILI associated lung hyperpermeability. (NV n = 6; NV + Simva n = 7; 6 h Vent. N = 7; 6 h Vent. + Simva n = 6; *P < 0.05, ***P < 0.001).