Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension

Table 4 Hemodynamic variables depending on whether the baseline value of the left ventricular function was either ≤45% (n = 34) or >45% (n = 71)

	LVEF ≤45%		LVEF >45%
	Before NE (introduction/increase)	After NE (introduction/increase)	Before NE (introduction/increase)	After NE (introduction/increase)
Heart rate, beats/min	96 ± 17	94 ± 17	93 ± 21	94 ± 20
MAP, mm Hg	54 ± 9	75 ± 9^a	54 ± 7	76 ± 9^a
DAP, mm Hg	38 ± 7	52 ± 9^a	38 ± 6	52 ± 8^a
CI, L/min/m²	2.9 ± 0.9	3.3 ± 0.9^a	3.2 ± 0.9	3.7 ± 1.1^a
SVI, ml/m²	32 ± 11	35 ± 12^a	36 ± 13	41 ± 15^a
GEDVI, ml/m²	719 ± 161	768 ± 190^a	683 ± 140	731 ± 157^a
CFI, per min	4.2 ± 1.4	4.4 ± 1.5	5.0 ± 1.6	5.4 ± 1.6^a
SVRI, dynes/sec/cm⁵/m²	1,588 ± 513	2,024 ± 616^a	1,435 ± 484	1,680 ± 535^a

CFI, cardiac function index; CI, cardiac index; DAP, diastolic arterial pressure; GEDVI, global end-diastolic volume index; HR, heart rate; LVEF, left ventricular function; MAP, mean arterial pressure; NE, norepinephrine; SVI, stroke volume index; SVRI, index of systemic vascular resistance.
^aP < 0.05 vs. before norepinephrine.

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