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Table 2 Final study cohort

From: Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective

Study Year published Year completed Trial origin Trial Reported as Paper#/abstract Design Allocation concealment Effect and sample size calculation Early stopping Sepsis/shock description Predominant patient type Primary outcome
Cooperative Study Group [32] 1963 NA USA Multicenter Paper Double-blind Yes No No 'Life threatening infections' Medical Hospital mortality
Klastersky and colleagues [41] 1971 1970 Belgium Singlecenter Paper Double-blind Yes No No 'Life threatening infections' Cancer 30-day mortality
Schumer [31] 1976 1975 USA Singlecenter Paper Double-blind NA No No Septic history, falling blood pressure and positive blood cultures Surgical 28-day mortality
Sprung and colleagues [43] 1984 1982 USA Two-centers Paper Open-label Yes No No SBP < 90 mmHg, decreased organ perfusion hypotension despite fluid infusion, and bacteraemia or identified infection source Medical Hospital mortality
Bone and colleagues [38] 1987 1985 USA Multicenter Paper Double-blind Yes No No Evidence of infection, fever/hypothermia tachypnoea, inadequate organ perfusion/dysfunction, SBP < 90 mmHg/decrease 40 mmHg Mixed SS development ≤14 days post admission; reversal SS ≤14 days; death ≤14 days
Luce and colleagues [46] 1988 1986 USA Singlecenter Paper Double-blind Yes Yes Yes Fever/hypothermia, SBP < 90 mmHg, blood culture or body-fluid positive Mixed ARDS development, Hospital mortality
Bollaert and colleagues [37] 1998 NA France Singlecenter Paper Double-blind Yes Yes Yes ACCP/SCCM criteria Mixed Shock-reversal
Briegel and colleagues [39] 1999 1996 Germany Singlecenter Paper Double-blind Yes Yes No ACCP/SCCM criteria Mixed Shock-reversal
Chawla and colleagues [47] 1999 NA USA Singlecenter Abstract Double-blind NA NA NA NA NA Shock-reversal
Yildiz and colleagues [45] 2002 1999 Turkey Singlecenter Paper Double-blind No No No ACCP/SCCM criteria Medical 28-day mortality
Annane and colleagues [36] 2002 1999 France Multicenter Paper Double-blind Yes Yes No Documented evidence of infection; fever/hypothermia; SBP < 90 mmHg, despite fluid and vasopressors; decreased organ perfusion; mechanical ventilation Mixed 28-day survival distribution in corticorophin non-responders
Tandan and colleagues [44] 2005 NA India Singlecenter Abstract Double-blind NA NA NA NA   28-day mortality
Oppert and colleagues [ 42] 2005 NA Germany Singlecenter Paper Double-blind Yes NA NA Tachycardia; Fever/hypothermia; Positive culture; SBP < 90 mmHg with CVP ≥10 mmHg,; vasopressors Medical Time to vasopressor cessation
Sprung and colleagues [8] 2008 2005 Europe Multicenter Paper Double-blind Yes Yes Yes Clinical evidence of infection; evidence of systemic response to infection; shock (within 72 hours), SBP <90 mmHg despite fluid infusion or vasporessors; inadequate organ perfusion/dysfunction Mixed 28-day mortality in corticorophin non-responders
  1. #Paper, full publication as a journal paper; ACCP, American College of Chest Physicians; ARDS, Acute Respiratory Distress Syndrome; CVP, central venous pressure; NA, not-available; SBP, systolic blood pressure; SCCM, Society of Critical Care Medicine; SS, septic shock.