| | |
Time after injury (hours)
|
|---|
| |
Control
|
4
|
8
|
12
|
18
|
24
|
|---|
|
MAP, mmHg
|
105 ± 1
|
108 ± 10
|
87 ± 4a
|
81 ± 4a
|
76 ± 11b
|
63 ± 2c
|
|
CO, L/min
|
3.8 ± 0.2
|
5.4 ± 0.4
|
5.4 ± 0.1
|
6.6 ± 0.6a
|
6.9 ± 0.5a
|
7.1 ± 0.3b
|
|
apH, -log10 [H+]
|
7.50 ± 0.02
|
7.60 ± 0.03
|
7.50 ± 0.07
|
7.51 ± 0.02
|
7.37 ± 0.04a
|
7.29 ± 0.06a
|
|
aBE, mmol/L
|
2.1 ± 0.8
|
3.9 ± 1.9
|
-0.4 ± 2.0
|
0.3 ± 1.3
|
-3.2 ± 1.8
|
-3.6 ± 2.0a
|
|
PaCO2, mmHg
|
31 ± 0.0
|
30 ± 2
|
32 ± 4
|
30 ± 1
|
34 ± 2
|
38 ± 3a
|
|
BCT, °C
|
39.6 ± 0.1
|
40.7 ± 0.7
|
41.0 ± 0.2
|
40.6 ± 0.1a
|
40.1 ± 0.4a
|
39.2 ± 0.5
|
|
WBC, K/μL
|
6.7 ± 1.4
|
3.2 ± 1.0a
|
1.8 ± 0.6b
|
2.2 ± 0.6b
|
1.8 ± 0.5b
|
1.1 ± 0.2c
|
- Values recorded before sacrifice of animals with sham injury (control) and at different time points after induction of sepsis following acute lung injury. Each group includes four animals.
- aBE, arterial base excess; apH, arterial pH; BCT, body core temperature; CO, cardiac output; MAP, mean arterial pressure; PaCO2, partial arterial carbon dioxide pressure; WBC, white blood cells. a P < 0.05, b P < 0.01, c P < 0.001 vs. control group.
