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Table 3 Adequate concentrations of the four drugs, with regard to renal dysfunction

From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

  meropenem (n = 16) ceftazidime (n = 18) cefepime (n = 19) piperacillin-tazobactam (n = 27)
T > 4 × MIC (%) 57 (25-100) 45 (8-100) 34 (10-100) 33 (0-100)
Adequate PK, n (%) 12 (75) 5 (28) 3 (16) 12 (44)
CrCl <50 mL/min (%) 5/6 (83) 3/9 (33) 2/12 (17) 10/14 (71)
CrCl >50 mL/min (%) 7/10 (70) 2/9 (22) 1/7 (14) 2/13 (15) *
  1. Data are expressed as counts (percentage) or median (range).
  2. CrCl, creatinine clearance; MIC, minimal inhibitory concentration; PK, pharmacokinetic.
  3. * P = 0.03 (vs. CrCl < 50 mL/min).