Skip to main content

Table 3 Adequate concentrations of the four drugs, with regard to renal dysfunction

From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

 

meropenem (n = 16)

ceftazidime (n = 18)

cefepime (n = 19)

piperacillin-tazobactam (n = 27)

T > 4 × MIC (%)

57 (25-100)

45 (8-100)

34 (10-100)

33 (0-100)

Adequate PK, n (%)

12 (75)

5 (28)

3 (16)

12 (44)

CrCl <50 mL/min (%)

5/6 (83)

3/9 (33)

2/12 (17)

10/14 (71)

CrCl >50 mL/min (%)

7/10 (70)

2/9 (22)

1/7 (14)

2/13 (15) *

  1. Data are expressed as counts (percentage) or median (range).
  2. CrCl, creatinine clearance; MIC, minimal inhibitory concentration; PK, pharmacokinetic.
  3. * P = 0.03 (vs. CrCl < 50 mL/min).
Back to article page

Critical Care

ISSN: 1364-8535