A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults

Table 7 Platelet values over time with actual and percent change from baseline by treatment

Platelets (×10⁹/L)		Lab values over time				Change from baseline (actual and percent)
		Baseline	Hour 24	Hour 72	Hour 120	to Hour 24		to Hour 72		to Hour 120
100 mg IV Ibuprofen	Average	222	210	270	325	-14	-7%	40	41%	112	109%
	SD	159	164	157	191	43	17	92	69	145	140
	N	31	30	28	27	30	30	28	28	27	27
	Min	41	36	73	39	-99	-41%	-191	-38%	-169	-77%
	Max	659	756	690	933	103	20%	230	269%	473	513%
200 mg IV Ibuprofen	Average	190	201	293	416	11	7%	101	82%	228	188%
	SD	111	127	190	239	63	27	148	99	194	180
	N	30	30	26	24	30	30	26	26	24	24
	Min	35	29	102	148	-197	-56%	-200	-57%	3	2%
	Max	477	492	965	1258	205	71%	678	412%	971	686%
400 mg IV Ibuprofen	Average	174	162	229	308	-9	-6%	55	54%	136	156%
	SD	116	110	126	149	36	23	103	69	168	161
	N	31	30	31	27	30	30	31	31	27	27
	Min	34	20	39	117	-87	-49%	-209	-41%	-301	-58%
	Max	516	464	562	866	115	64%	367	243%	685	533%
Placebo	Average	220	213	268	339	-7	-4%	43	32%	127	98%
	SD	124	136	137	137	61	28	84	56	114	122
	N	28	28	27	24	28	28	27	27	24	24
	Min	48	5	22	61	-163	-97%	-192	-87%	-162	-64%
	Max	541	448	502	594	130	44%	178	213%	301	521%

ISSN: 1364-8535