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Table 2 Neuropsychological test outcomes (mean ± SD) at 0 (baseline), 2 and 8 hours after LPS administration

From: Endotoxemia-induced inflammation and the effect on the human brain

 

LPS group (n = 15)

Reference group (n = 10)

P value (between group)

Age

(Dutch) STAI total

22.8 ± 2.2

25.5 ± 2.5

0.87*

 

32.7 ± 1.5

29.1 ± 3.7

0.13*

Neuropsychological test

t = 0

t = 2

t = 8

P value (within group)

t = 0

t = 2

t = 8

P value (within group)

 

Stroop A (in seconds) 1

39 ± 2

35 ± 2

35 ± 2

0.0001

37 ± 5

34 ± 4

34 ± 4

0.001

0.49

Stroop B (in seconds) 1

51 ± 3

45 ± 3

43 ± 2

0.0001

48 ± 7

44 ± 7

43 ± 7

0.001

0.45

Stroop C (in seconds) 1

75 ± 6

65 ± 4

64 ± 4

0.003

67 ± 10

62 ± 12

61 ± 11

0.004

0.23

Pasat 2

49 ± 2

50 ± 2

56 ± 2

0.001

50 ± 7

54 ± 4

54 ± 5

0.031

0.07

Digits forward 2

11 ± 1

12 ± 1

11 ± 1

0.115

10 ± 2

11 ± 1

11 ± 2

0.235

0.81

Digits backward 2

8 ± 1

9 ± 1

9 ± 1

0.30

9 ± 2

9 ± 1

9 ± 2

0.454

0.65

Digits total 2

19 ± 1

20 ± 1

20 ± 1

0.066

19 ± 4

20 ± 3

21 ± 4

0.203

0.63

Pegboard 1

64 ± 2

59 ± 2

61 ± 2

0.037

58 ± 5

56 ± 6

56 ± 7

0.362

0.35

Symbol substitution task2

87 ± 3

99 ± 4

101 ± 3

0.0001

98 ± 14

108 ± 17

112 ± 19

0.0001

0.53

  1. All values are means ± SD unless other reported.
  2. * Unpaired T-test.
  3. 1 Decrease indicates an improvement of the test.
  4. 2 Increase indicates an improvement of the test.
  5. Reading speed was measured by Stroop A-B-C word naming test.
  6. Attention under time pressure was measured by the paced auditory serial addition test (PASAT).
  7. Working memory was tested in numbers with the Digits forward and backward test.
  8. The fine motor control was tested with the Grooved Pegboard test.
  9. Psychomotor speed capacity was measured by the symbol substitution task.
  10. LPS, lipopolysaccharide; SD, standard deviation; STAI, Dutch State-Trait Anxiety Inventory scale.
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Critical Care

ISSN: 1364-8535