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Table 1 Summary of patient characteristics stratified by multiple organ dysfunction, sepsis severity and mortality

From: 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study

 

Multiple organ dysfunction

Sepsis severity

ICU mortality

Patient characteristics

Median (quartiles) or %

Non-MODS

(n = 86)

MODS

(n = 121)

Severe sepsis

(n = 118)

Septic shock

(n = 89)

Survivors

(n = 129)

Non-survivors

(n = 78)

Demographics

      

Age (years)

58.5 (48-68)*

70 (59-77)*

61 (51-71)*

72 (59-77)*

61 (50-70)*

72.5(61-79)*

Male sex, %

45.3

53.7

46.6

55.1

45.0

59.0

Previous or preexisting conditions

      

Days of complaint before admission, (days)

4 (2-7)

4 (1-10)

4 (2-8)

4 (1-9)

4 (1-7.5)

4 (2-10)

Pulmonary hospitalisation in the past two years, %

27.9

24.8

31.4*

19.1*

27.9

23.1

Cachexia, %

12.8

17.4

12.7

19.1

14.0

17.9

Nosocomial pneumonia, %

25.6*

44.6*

30.5*

44.9*

32.6

43.6

Ischemic heart disease, %

33.7

43.8

37.3

42.7

36.4

44.9

COPD, %

43.0

33.1

42.4

30.3

39.5

33.3

Hypertension, %

55.8

62.8

59.3

60.7

58.1

62.8

Diabetes mellitus, %

24.4

27.3

26.3

25.8

24.0

29.5

Active and ever (>15 years) smoking, %

46.5

42.1

46.6

40.4

46.5

39.7

Alcohol consumption >1 glass/day, %

9.3

13.2

9.3

14.6

10.9

12.8

ICU conditions

      

28 days mortality, %

0.0*

62.8*

9.3*

73.0*

0.0*

97.4*

ICU mortality, %

0.0*

64.5*

9.3*

75.3*

-

-

APACHE II score at admission

18 (14-22)*

24 (18.5-30.5)*

19 (15-23)*

25 (20-31)*

19 (15-23)*

25 (22-31)*

DIC score at admission

0 (0-2)*

3 (0-4)*

0 (0-2)*

3 (2-5)*

0 (0-2)*

3 (2-4)*

ICU length of stay, (days)

8 (5-12)

8 (5-16.5)

8 (5-12)

8 (4.5-16.5)

9 (5-15)

8 (4-12)

Horowitz quotient of invasively ventilated patients, (PaO2/FiO2)

269.0 (161.3-342.3)*

179.6 (126.2-232.4)*

222.0 (149.9-335.4)*

175.2 (119.7-229.7)*

197.5 (139.1-305.5)

188.3 (124.2-241.6)

ARDS, %

7.0*

24.0*

8.5*

28.1*

11.6*

25.6*

Invasive ventilation, %

52.3*

97.5*

62.7*

100.0*

65.9*

100.0*

Length of invasive ventilation, (days)

5 (3.5-7.5)*

8 (4-13.3)*

5.5 (4-10.3)

7 (4-14)

6 (4-13)

7 (4-12)

Tracheotomy, %

5.8*

14.9*

10.2

12.4

10.9

11.5

Hemodialysis, %

7.0*

17.4*

9.3

18.0

9.3*

19.2*

Infection types

      

Unconfirmed, %

55.8*

31.4*

49.2*

31.5*

45.0

35.9

Confirmed, %

      

Gram positive

10.5

19.3

11.7

21.3

15.5

18.0

Gram negative

52.6

57.8

60.0

52.5

52.1

62.0

Atypical pneumonia (Chlamydia, Mycoplasma, Legionella)

23.7

14.5

18.3

16.4

21.1

12.0

Mixed

13.2

8.4

10.0

9.8

11.3

8.0

  1. *Statistical significance (P < 0.05) of comparing the groups of non-MODS vs. MODS, severe sepsis vs. septic shock and survivors vs. non-survivors by Mann-Whitney or Pearson Chi-square tests
  2. APACHE II, acute physiology and chronic health evaluation II; ARDS, acute respiratory distress syndrome; COPD, chronic obstructive pulmonary disease; DIC, disseminated intravascular coagulation; FiO2, fraction of inspired oxygen; MODS, multiple organ dysfunction syndrome; PaO2, partial pressure of arterial oxygen.
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