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Table 2 Amikacin pharmacokinetics in patients with or without renal dysfunction

From: Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

  All
(n = 74)
CrCl <50 ml/min
(n = 38)
CrCl >50 ml/min
(n = 36)
Vd1 (central) (L) 0.23 (0.18-0.28) 0.23 (0.19-0.35) 0.22 (0.17-0.26)
Vd2 (peripheral) (L) 0.18 (0.11-0.23) 0.19 (0.12-0.29) 0.18 (0.11-0.23)
Vss (L/kg) 0.41 (0.29-0.51) 0.42 (0.31-0.54) 0.40 (0.28-0.49)
t1/2 (hours) 4.6 (3.2-7.8) 7.6 (4.6-13.2) 3.3 (2.5-4.6)a
CL (ml/min/kg) 1.98 (1.28-3.54) 1.29 (0.84-2.01) 3.49 (1.94-5.04)a
AUC (mg × h/ml) 798 (478-1285) 1,177 (833-1961) 466 (368-763)a
Cmax (μg/ml) 91.7 (73.1-112.8) 91.0 (70.6-112.8) 92.3 (74.1-109.4)
Peak (μg/ml) 72.7 (61.7-90.2) 71.5 (57.3-86.3) 75.7 (63.1-92.9)
Cmin (μg/ml) 6.7 (2.1-15.4) 15.4 (8.0-21.4) 2.6 (1.3-6.0)a
  1. Data are expressed as median (IQR). a p < 0.001. AUC, area under the curve; t1/2, elimination half-time; CL, clearance; CrCl, creatinine clearance; Vd, volume of distribution; Vss, total volume of distribution.