Skip to main content

Table 3 Combined two-by-two correlations and multiple regression between clinical and laboratory parameters, and PK values.

From: Prospective monitoring of cefepime in intensive care unit adult patients

Clinical and laboratory parameters   Pharmacokinetic parameters 1,2(number of data points)
  K β T 1/2β MRTiv CLCEF V β V SS
Weight 0.08 -0.05 -0.04 -0.34 -0.42** -0.47**
  (28) (28) (28) (28) (28) (28)
Age -0.65** 0.58* 0.61* -0.75** -0.50** -0.34
  (28) (28) (28) (28) (28) (28)
Proteins 0.52* -0.27 -0.28 0.24 -0.13 -0.29
  (26) (26) (26) (26) (26) (26)
Albumin 0.63* -0.31 -0.32 0.21 -0.27 -0.43**
  (26) (26) (26) (26) (26) (26)
Hemoglobin 0.07 0.06 0.07 -0.42** -0.58** -0.59**
  (28) (28) (28) (28) (28) (28)
Na + -0.11 0.01 -0.01 0.17 0.38 0.38
  (28) (28) (28) (28) (28) (28)
Creatinine -0.78** 0.91* 0.91* -0.69** -0.31 -0.19
  (27) (27) (27) (27) (27) (27)
CL Cr 0.79* -0.81** -0.82** 0.88* 0.51* 0.35
  (27) (27) (27) (27) (27) (27)
pCO 2 0.28 -0.41 -0.42** 0.03 -0.14 -0.20
  (23) (23) (23) (23) (23) (23)
HCO 3 0.33 -0.42** -0.41 -0.05 -0.27 -0.33
  (23) (23) (23) (23) (23) (23)
Cefepime dose (mg/kg) 0.19 -0.17 -0.17 0.57* 0.51* 0.53*
  (28) (28) (28) (28) (28) (28)
  1. 1Significant Pearson's coefficients with P < 0.05 are highlighted by asterisk. One asterisk indicates positive (direct) correlations and two asterisk indicate negative (inverse) correlations.
  2. 2For each PK parameters, the most pertinent physiological parameters according to the result of the two by two correlations were included as independent variable in a forward stepwise multiple regression. Creatinine serum levels were excluded from the analysis (in spite of a significant correlation with some pK parameters) because of a non-normal (bimodal) distribution. Creatinine clearance, which shares similar biological information, was more regularly distributed. Remaining primary predictive variable (P < 0.05) after this procedure are marked in bold italic font in the table.