Prospective monitoring of cefepime in intensive care unit adult patients

Table 3 Combined two-by-two correlations and multiple regression between clinical and laboratory parameters, and PK values.

Clinical and laboratory parameters		Pharmacokinetic parameters ^1,2(number of data points)
	K _β	T _1/2β	MRT_iv	CL_CEF	V _β	V _SS
Weight	0.08	-0.05	-0.04	-0.34	-0.42**	-0.47**
	(28)	(28)	(28)	(28)	(28)	(28)
Age	-0.65**	0.58*	0.61*	-0.75**	-0.50**	-0.34
	(28)	(28)	(28)	(28)	*(28)*	(28)
Proteins	0.52*	-0.27	-0.28	0.24	-0.13	-0.29
	(26)	(26)	(26)	(26)	(26)	(26)
Albumin	0.63*	-0.31	-0.32	0.21	-0.27	-0.43**
	*(26)*	(26)	(26)	(26)	(26)	(26)
Hemoglobin	0.07	0.06	0.07	-0.42**	-0.58**	-0.59**
	(28)	(28)	(28)	(28)	*(28)*	*(28)*
Na ⁺	-0.11	0.01	-0.01	0.17	0.38	0.38
	(28)	(28)	(28)	(28)	(28)	(28)
Creatinine	-0.78**	0.91*	0.91*	-0.69**	-0.31	-0.19
	(27)	(27)	(27)	(27)	(27)	(27)
CL _Cr	0.79*	-0.81**	-0.82**	0.88*	0.51*	0.35
	*(27)*	*(27)*	*(27)*	*(27)*	(27)	(27)
pCO ₂	0.28	-0.41	-0.42**	0.03	-0.14	-0.20
	(23)	(23)	(23)	(23)	(23)	(23)
HCO ₃	0.33	-0.42**	-0.41	-0.05	-0.27	-0.33
	(23)	(23)	(23)	(23)	(23)	(23)
Cefepime dose (mg/kg)	0.19	-0.17	-0.17	0.57*	0.51*	0.53*
	(28)	(28)	(28)	*(28)*	(28)	(28)

¹Significant Pearson's coefficients with P < 0.05 are highlighted by asterisk. One asterisk indicates positive (direct) correlations and two asterisk indicate negative (inverse) correlations.
²For each PK parameters, the most pertinent physiological parameters according to the result of the two by two correlations were included as independent variable in a forward stepwise multiple regression. Creatinine serum levels were excluded from the analysis (in spite of a significant correlation with some pK parameters) because of a non-normal (bimodal) distribution. Creatinine clearance, which shares similar biological information, was more regularly distributed. Remaining primary predictive variable (P < 0.05) after this procedure are marked in bold italic font in the table.

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