Significant correlations between physiological and pharmacokinetic parameters. Cefepime elimination closely correlated with creatinine clearance (panels A and B), as abundantly described [15–20]. In addition, more intricate parameters also showed independent negative and positive correlations with drug elimination, as for instance the concentrations of hemoglobin (panel C) and plasma albumin (panel D). Corresponding coefficients of correlations (r values) are indicated. Additional correlations are presented in Table 3.