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Table 1 Clinical characteristics and outcomes of H1N1(v) critically ill immunocompromised patients

From: Clinical features of H1N1 2009 infection in critically ill immunocompromised patients

Patient

Type of immune deficiency

Chemotherapy

Immuno- suppressive agents

Lymphocyte count

Time, in days, from respiratory symptoms to ICU admission

Ventilatory support

Superinfection

Anti-infectious agentsa

Outcome

1

Chronic myeloid leukemia

No

No

4,000

3

NIV

Clinically documented

C3G/macrolide

Alive

2

Allogeneic BMT (12 months ago) with GVHD

No

Yes (steroid/CIs)

800

1

MV

Clinically documented

Piperacillin/FQ

Dead

3

Allogeneic BMT (15 months ago) with GVHD

No

Yes (steroid/CIs)

600

1

NIV

Escherichia coli + Aspergillus fumigatus

Imipeneme/FQ

Dead

4

Autologous BMT for multiple myeloma

Yes

Yes (steroid)

50

5

None

Clinically documented

Piperacillin/macrolide

Alive

5

Renal transplantation

Yes

Yes (steroid/CIs/MMF)

1,200

5

MV

Pseudomonas aeruginosa

Piperacillin/macrolides

Dead

6

HIV

No

No

1,800

3

None

Streptococcus pneumoniae

C3G/macrolide

Alive

7

Autologous BMT for multiple myeloma

Yes

Yes (steroid)

100

5

MV

Clinically documented

Piperacillin/macrolide

Alive

8

Myelodysplasia

Yes

Yes (steroid)

2,000

3

MV

E. coli

Piperacillin/macrolide

Dead

9

Mantle cell lymphoma

No

No

100

2

NIV and MV

S. pneumoniae

C3G/macrolide

Alive

10

Solid organ transplantation

No

Yes (steroid)

2,000

2

None

S. pneumoniae

C3G/macrolide

Alive

  1. aAll patients were receiving oseltamivir. BMT, bone marrow transplantation; C3G, third-generation cephalosporin; CI, calcineurin inhibitor; FQ, fluoroquinolone; GVHD, graft-versus-host disease; ICU, intensive care unit; MMF, mycophenolate mofetil; MV, mechanical ventilation; NIV, non-invasive mechanical ventilation.