Table 2 Gas exchange and hemodynamic variables
| Â | Baseline | Injury | PSV | BIPAP+SBmean |
|---|---|---|---|---|
Gas exchange | Â | Â | Â | Â |
PaO2/FIO2 (mmHg) | 513 ± 62 (489.6-547.2) | 119 ± 30* (92.0-143.1) | 264 ± 127 (136.0-378.7) | 246 ± 112 (143.1-332.5) |
(%) | 5.5 ± 1.4 (4.4-6.5) | 33.9 ± 12.8* (24.7-39.7) | 16.9 ± 10.4 (6.7-24.3) | 19.8 ± 12.1 (11.6-28.7) |
PaCO2 (mmHg) | 34 ± 6 (29.4-39.7) | 39 ± 8* (30.1-46.5) | 48 ± 6 (44.2-55.2) | 59 ± 13†(46.9-66.2) |
Hemodynamics | Â | Â | Â | Â |
CO (L/min) | 3.2 ± 0.8 (2.4-3.8) | 3 ± 0.8 (2.3-3.8) | 4.3 ± 1.4 (2.8-5.3) | 4.2 ± 1.2 (3.2-5.2) |
HR (/min) | 77 ± 13 (69-83) | 75 ± 12 (65-86) | 91 ± 18 (83-100) | 91 ± 19 (77-110) |
MAP (mmHg) | 73 ± 9 (67-79) | 69 ± 12 (62-75) | 75 ± 8 (71-77) | 79 ± 14 (68-98) |
MPAP (mmHg) | 22 ± 4 (20-24) | 30 ± 5* (27-32) | 31 ± 5 (26-35) | 33 ± 6 (30-36) |
CVP (mmHg) | 10 ± 3 (8-12) | 11 ± 2 (10-11) | 9 ± 2 (8-10) | 9 ± 2 (7-11) |
PCWP (mmHg) | 13 ± 2 (12-14) | 14 ± 2 (12-15) | 13 ± 4 (11-14) | 12 ± 2 (11-15) |
- Values are given as mean ± standard deviation. Baseline, before induction of acute lung injury; injury, after induction of acute lung injury. * P < 0.05 vs. baseline; †P < 0.05 vs. PSV.
- BIPAP+SBmean, biphasic positive airway pressure + spontaneous breathing; CO, cardiac output; CVP, central venous pressure; FiO2, fraction of inspired oxygen; HR, heart rate; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PaCO2, partial pressure of arterial carbon dioxide; PaO2, partial pressure of arterial oxygen; PCWP, pulmonary artery occlusion pressure; PSV, pressure support ventilation;
, mixed venous admixture.