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Table 1 Main characteristics of the study population

From: Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication

Id Intoxicant Serum drug level (μg/ml) Creatinine (mg/dl) pH Lactate (mM) Monitoring SAPS II ICU outcome
1 Metformin 70 6.4 7.21 22 CI; 58 S
2 Metformin 63 12.4 6.95 33 CI; 53 S
3 Metformin NA 10.8 6.76 21 CI; 61 S
4 Metformin NA 15.2 7.06 18 CI; 51 S
5 Metformin NA 9.0 6.63 21 CI; 55 S
6 Metformin NA 10.3 6.82 21 CI; ScvO2 87 S
7 Metformin NA 10.8 6.70 24 CI; ScvO2 74 S
8 Metformin 61 1.9 7.27 10 CI; 83 NS
9 Metformin NA 13.2 6.79 21 CI; ScvO2 63 S
10 Metformin NA 4.7 7.13 19 CI; ScvO2 66 S
11 Metformin 53 4.5 <6.80 16 CI; 87 NS
12 Metformin 65 8.4 6.76 22 ScvO2 43 S
13 Phenformin 480§ 9.5 6.91 13 ScvO2 59 S
14 Metformin 100 5.8 7.26 10 ScvO2 58 S
15 Metformin 63 4.2 6.89 18 ScvO2 53 NS
16 Metformin NA 13.0 6.93 17 ScvO2 67 S
17 Metformin 19 9.9 6.62 19 ScvO2 62 S
18 Metformin NA 6.1 <6.80 24 ScvO2 70 NS
19 Metformin 100 7.6 6.87 16 ScvO2 45 S
20 Metformin 25 9.3 6.81 15 ScvO2 44 S
21* Metformin 70 4.8 7.22 11 ScvO2 66 S
22* Metformin 44 10.0 6.93 14 ScvO2 55 S
23 Metformin NA 13.8 7.21 6 ScvO2 39 S
24 Metformin NA 7.1 6.93 17 ScvO2 65 NS
  1. The first available serum drug concentration (§ phenformin in ng/ml; blood sample obtained with ongoing renal replacement therapy), creatinine level, arterial blood pH and plasma lactate level, available data (CI, cardiac index; ScvO2, central venous oxymetry; , mixed venous oxymetry), severity of the disease (expressed as Simplified Acute Physiology Score (SAPS) II score) and outcome (S = survivor; NS = non survivor) are reported. Target values in patients on metformin or phenformin are less than 4 μg/ml and less than 140 ng/ml, respectively. ICU, intensive care unit; NA, not available; * patients admitted to the Nephrology Unit.