Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial

Table 4 Intraoperative data, hemodynamics and volume replacement

	GDT group n = 30	Control group n = 30	P
Duration of anesthesia (min)	357 ± 92	365 ± 113	0.75
Surgery time (min)	280 ± 84	297 ± 109	0.51
Urinary output (ml·kg^-1·h^-1)	2.2 ± 1.5	1.6 ± 1.6	0.16
Blood loss (ml)	1090 ± 1385	892 ± 747	0.49
Intraoperative hemodynamics^#
Heart rate (bpm)	69 ± 15	70 ± 16	0.31
MAP (mmHg)	80.6 ± 16.1	74.6 ± 15.5	0.006*
CVP (mmHg)	12 ± 5	10 ± 4	0.01*
SVI (ml m^-2)	38.8 ± 9.1	-	-
SVRI (dyne·s·cm^-5·m^-2)	2101 ± 459	-	-
CI (L·min^-1·m^-2)	2.7 ± 0.8	-	-
Crystalloid volume replacement (ml)	2489 ± 805	3153 ± 1264	0.02*
Colloid volume replacement (ml)	1188 ± 550	817 ± 467	0.006*
PRBC (ml·kg^-1·h^-2)	1.3 ± 1.8	0.9 ± 1.0	0.28
FFP (ml·kg^-1·h^-2)	0.5 ± 1.3	0.2 ± 1.6	0.35
Total volume infused intraoperatively (ml)	4528 ± 2317	4494 ± 1561	0.95

#, mean of values taken automatically every five minutes; * significant; bpm, beats per minute; CI, cardiac index; CVP, central venous pressure; GDT, goal-directed therapy; FFP, fresh frozen plasma; MAP, mean arterial pressure; PRBC, packed red blood cells; SVI, stroke volume index; SVRI, systemic vascular resistance index. All data presented as mean ± standard deviation.

ISSN: 1364-8535