- Meeting abstract
Inhaled nitric oxide in infants and children with ARDS
Critical Care volume 4, Article number: P128 (2000)
To evaluate the effects of inhaled nitric oxide on gas exchange and outcome in pediatric patients with acute respiratory distress syndrome (ARDS).
Case series report.
Pediatric intensive care unit of a tertiary care children's hospital.
Seventeen pediatric patients with ARDS requiring mechanical ventilation with an FiO2 >0.5 at a positive end-expiratory pressure >6 cmH2O, and whose PaO2/FiO2ratio was <100 torr were enrolled in this study.
Initially inhaled (NO) was applied at 10 ppm using a microprocessor based system. A positive response after 15 min of NO inhalation was defined as an increase in arterial oxygen saturation >5%.
Measurements and main results
At the start of NO inhalation the oxygenation (OI=Paw*FiO2*100/PaO2) and ventilation (VI=PaCO2*PIP*RR/1000) indices were 29± 2.8 and 43± 4.1, respectively, the PaO2/FiO2 ratio was 69± 7 torr, and the static compliance of the respiratory system 0.51± 0.04 ml/cmH2O/kg. An initial positive response to inhaled NO was observed in 59% of patients.
Inhaled NO significantly improves oxygenation in 59% of infants and children with ARDS. However, an initial positive response to inhaled NO does not reduce the need for ECMO support and does not influence duration of mechanical ventilation and outcome of pediatric patients with severe ARDS.
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Cite this article
Zobel, G., Rödl, S., Trop, M. et al. Inhaled nitric oxide in infants and children with ARDS. Crit Care 4 (Suppl 1), P128 (2000). https://doi.org/10.1186/cc848