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  • Open Access

Invasive mechanical ventilation in cancer patients: prior non-invasive ventilation is a poor prognostic factor

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  • 1,
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  • 1,
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  • 1
Critical Care201014 (Suppl 1) :P213

https://doi.org/10.1186/cc8445

  • Published:

Keywords

  • Cancer Patient
  • Prognostic Factor
  • Solid Tumour
  • Bilirubin
  • Respiratory Failure

Introduction

Prior non-invasive ventilation (NIV) is associated with an increased mortality in patients with haematological malignancies and acute respiratory failure treated by invasive mechanical ventilation (IMV).

Methods

We have assessed whether NIV failure is an independent prognostic factor for hospital discharge in a general cancer population treated by IMV. One hundred and six patients with solid tumours and 58 patients with haematological malignancies were eligible for this retrospective study; 41 were treated by NIV before IMV.

Results

The main indications for mechanical ventilation were sepsis/shock (35%), acute respiratory failure (33%), cardiopulmonary resuscitation (16%) and neurologic disease (10%). Respectively, 35%, 28% and 24% of the patients were extubated, discharged from the ICU and from the hospital. For patients treated with NIV prior to IMV, the rates were 22%, 17% and 10%, respectively. In multivariate analysis, three variables were independently associated with a decreased probability of being discharged from the hospital: NIV use before IMV (OR = 0.30, 95% CI: 0.09 to 0.95; P = 0.04); leucopenia (OR = 0.21, 95% CI: 0.06 to 0.77; P = 0.02) and serum bilirubin >1.1 mg/dl (OR = 0.38, 95% CI: 0.16 to 0.94; P = 0.04).

Conclusions

NIV failure before IMV is an independent poor prognostic factor in cancer patients treated by IMV.

Authors’ Affiliations

(1)
Institut Jules Bordet, Bruxelles, Belgium

Copyright

© BioMed Central Ltd. 2010

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